Heritability of Early Repolarization

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Heritability of early repolarization: a population-based study.

BACKGROUND Early repolarization (ER), defined by J-point elevation in 12-lead ECG, was recently associated with increased risk for idiopathic ventricular fibrillation and cardiovascular mortality. The determinants of ER are unknown. We investigated its heritability in a large, family-based cohort. METHODS AND RESULTS The study sample comprised 1877 individuals from 505 white nuclear families ...

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Letter by Hayashi et al regarding article, "Heritability of early repolarization: a population-based study".

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Early repolarization (ER) on ECG was initially described in 1936 and has been considered a benign ECG finding for more than half a century. However, in 2008, a seminal study by Haïssaguerre et al challenged this view by demonstrating an association between ER and an increased risk of idiopathic ventricular fibrillation (VF). To reconcile these apparently contradictory views, as well as to bette...

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1520 The early repolarization (ER) pattern (ERP), initially described as elevation of the ST segment of ≥1 leads on the 12-lead ECG, has long been considered a benign phenomenon. However, more recent studies have demonstrated positive, negative, and neutral associations between an ERP and various end points, including all-cause, cardiac, and arrhythmic mortality. These recent studies have used ...

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ژورنال

عنوان ژورنال: Circulation: Cardiovascular Genetics

سال: 2011

ISSN: 1942-325X,1942-3268

DOI: 10.1161/circgenetics.110.958298